Generalized linear mixed models to identify demographic and clinical predictors of self-reported work disability in SSc.
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | Odds ratio | 95% CI | Odds ratio | 95% CI | Odds ratio | 95% CI | |
| Age | 1.008 | 0.979 1.037 | 1.014 | 0.984 1.046 | 1.014 | 0.983 1.047 | 0.999 | 0.966 1.033 |
| Female | 1.246 | 0.649 2.392 | 1.365 | 0.701 2.659 | 1.377 | 0.702 2.701 | 1.109 | 0.538 2.284 |
| White | 1.163 | 0.533 2.539 | 1.331 | 0.606 2.923 | 1.220 | 0.552 2.694 | 1.232 | 0.523 2.902 |
| Education | 0.618 | 0.377 1.012 | 0.668 | 0.401 1.111 | 0.630 | 0.376 1.056 | 0.622 | 0.355 1.089 |
| Comorbidity score | 1.135 | 1.072 1.202 | 1.101 | 1.036 1.169 | 1.077 | 1.012 1.147 | 1.075 | 1.005 1.151 |
| Disease duration | 1.033 | 1.001 1.066 | 1.041 | 1.007 1.076 | 1.042 | 1.008 1.077 | 1.050 | 1.013 1.088 |
| Diffuse skin involvement | 1.890 | 1.134 3.151 | 1.843 | 1.090 3.116 | 1.772 | 1.042 3.016 | 1.290 | 0.724 2.300 |
| PGA of disease severity | 1.312 | 1.162 1.481 | 1.257 | 1.109 1.424 | 1.252 | 1.104 1.420 | 1.093 | 0.948 1.260 |
| Pain | 1.212 | 1.102 1.333 | 1.152 | 1.040 1.277 | 1.000 | 0.886 1.128 | ||
| Fatigue* | 0.967 | 0.942 0.993 | 0.987 | 0.959 1.016 | ||||
| HAQ | 4.881 | 2.854 8.348 | ||||||
| AUC 76.6%, BIC 467.4 | AUC 79.2%, BIC 457.3 | AUC 80.1%, BIC 456.87 | AUC 84.7%, BIC 423.6 | |||||
↵* Lower scores indicate worse fatigue. PGA: physician global assessment; HAQ: Health Assessment Questionnaire; CI: confidence interval; AUC: area under the ROC curve; BIC: Bayesian information criterion.