Table 5.

Alkaline phosphatase in relationship to SSc-related autoantibodies.

	Mean Difference, IU/l^*	95% CI	p	Adjusted Mean Difference, IU/l^*	Adjusted 95% CI^†	Adjusted p^†
CENP-B	9.50	2.52 to 16.47	0.008	5.50	−0.03 to 11.03	0.051
ATA	7.23	0.63 to 13.84	0.031	9.56	3.19 to 15.93	0.003
Anti-RNAP	−9.33	−14.01 to 4.66	0.001	−7.87	−14.4 to−1.34	0.019

↵* Mean difference in alkaline phosphatase levels between antibody-positive and negative patients.
↵^† Adjusted in a bivariate model for the combined marker of MIT3 or sp100. CENP-B: anticentromere B antibodies; ATA: antitopoisomerase I antibodies; Anti-RNAP: anti-RNA-polymerase III antibodies.