Synergistic effects of IL-1ß, TNF-α, IL-17 on CCL20 production by rheumatoid fibroblast-like synovial cells.
| Cytokines | Concentrations of CCL20 |
|---|---|
| IL-1ß, 100 pg/ml | 166.5 ± 222.8 |
| TNF-α (100 ng/ml) | 34.2 ± 40.0 |
| IL-17 (100 ng/ml) | 29.4 ± 54.1 |
| IL-1ß + TNF-α (50 ng/ml) | 349.8 ± 313.4* |
| IL-ß+IL-17 (50 ng/ml) | 225.8 ± 225.8* |
| IL-ß+IFN-γ (100 U/ml) | 69.1 ± 103.3* |
Differences in CCL20 production from FLS stimulated by IL-1ß, IL-1ß+TNF-α, or IL-1ß+IL-17 or IL-1ß+IFN-γ were analyzed using nonparametric paired Wilcoxon test.
↵* p < 0.01, significantly different from CCL20 production by IL-1ß stimulation alone.