Association of clinical manifestations and genotype/haplotype of SNP in CRP gene.
| 1185 | p | TACGCA(ht1) | p | TGCGCG(ht2) | p | ||||
|---|---|---|---|---|---|---|---|---|---|
| CC n = 122 (%) | TC, TT n = 26 (%) | TACGCA n = 172 (%) | —* n = 124 (%) | TGCGCG n = 29 (%) | —* n = 267 (%) | ||||
| Oral ulcer | 65 (53.3) | 14 (53.9) | NS | 87 (50.6) | 71 (57.3) | NS | 14 (48.3) | 144 (53.9) | NS |
| Arthritis | 87 (71.3) | 21 (80.7) | NS | 123 (71.5) | 93 (75.0) | NS | 22 (85.9) | 194 (72.7) | NS |
| Serositis | 21 (17.2) | 6 (23.1) | NS | 27 (15.7) | 27 (21.8) | NS | 5 (17.2) | 49 (18.4) | NS |
| Photosensitivity | 32 (26.2) | 5 (19.2) | NS | 43 (25.0) | 31 (25.0) | NS | 11 (37.9) | 63 (23.6) | NS |
| Malar rash | 43 (35.3) | 12 (46.2) | NS | 62 (36.1) | 48 (38.7) | NS | 11 (37.9) | 99 (37.1) | NS |
| Nephritis | 39 (32.0) | 9 (34.6) | NS | 53 (30.8) | 43 (34.7) | NS | 10 (34.5) | 86 (32.2) | NS |
| Leukopenia | 61 (50.0) | 13 (50.0) | NS | 91 (52.9) | 57 (46.0) | NS | 13 (44.8) | 135 (50.6) | NS |
| Thrombocytopenia | 23 (18.8) | 10 (38.5) | 0.043 | 37 (21.5) | 29 (23.4) | NS | 6 (20.7) | 60 (22.5) | NS |
| Anti-dsDNA antibody | 82 (67.2) | 19 (73.1) | NS | 118 (68.6) | 84 (67.7) | NS | 17 (58.6) | 185 (69.3) | NS |
| Hypocomplementemia | 88 (72.1) | 19 (73.1) | NS | 131 (76.2) | 83 (66.9) | 0.037 | 16 (55.2) | 198 (74.2) | 0.030 |
| Anticardiolipin antibody | 50 (53.2) | 16 (66.7) | NS | 71 (51.8) | 61 (61.6) | NS | 13 (52.0) | 119 (56.4) | NS |
Logistic regression analysis was applied to control for age and gender as covariables. NS = not significant; ACA = anticardiolipin antibody.
↵* Did not have haplotype.