Case-control studies on silica exposure and SSc.
| Author/location | Methods | Findings |
|---|---|---|
| Silman, 199269, United Kingdom | Clinic based (dates not specified) | No cases with probable silica exposure |
| 56 male cases | 2 cases with probable silica exposure | |
| 56 age, sex and clinic-matched controls | Clinic controls: OR = 1.0 (0.1–7.2) | |
| 41 age and sex-matched friend-controls | Friend controls: OR = 1.4 (0.1–16.1) | |
| Exposure: assessment of jobs (length not specified) and self-reported exposures | ||
| Bovenzi, 199570, Italy | Clinic based: (1976–91) | Men: OR = 5.2 (0.48–74.1) |
| 21 cases (5 men, 16 women)Women: no exposed cases | ||
| 42 age and sex matched clinic controls | ||
| Exposure: Assessment of all jobs held ≥ 6 mo | ||
| Burns, 199671, Michigan, USA | Population based: (1985–91) | Working with/around silica: OR = 1.5 (0.7–2.9) |
| 274 female cases, 1184 age, sex and region-matched controls Exposure: assessment of jobs held ≥ 3 months/history of jobs held ≥ 5 yrs | Grinding, pottery, dental lab: OR = 1.2 (0.8–1.9) | |
| Englert, 200013, Australia | Population based; 160 male cases; 83 age and sex-matched controls | OR = 3.93 (1.84–8.54); OR = 2.51 (1.28–4.98), (adjusted by socioeconomic level) |
| Australia, Edenhope, 200527 | Population based: (1991) | |
| 5035 men, 4795 women; 2 age, sex and region-matched controls per case | 6 SSc cases; prevalence = 6.1/10,000; RR = 10.2 (4.5–23) | |
| Comparison: SSc estimated prevalence in the population | ||
| Exposure/occupation: phone survey about work held > 6 mos | ||
| Mora, 200372, Argentina, Buenos Aires | Clinic based: (1998–2002); 20 patients (15 women, 5 men); 61 sex and age-matched controls Exposure: structured questionnaire designed by environment hygienists about silica-related tasks held > 6 mos | 12 exposed cases/4 exposed controls; OR = 21 (4.7–21); 8 female exposed cases; OR = 24.6 (3.6–216); 4 male exposed cases; OR = 28 (1.4–1200) |
| Bovenzi, 200473, Italy | Clinic based: (1997–1999); 46 women, 9 men; 153 sex and age-matched controls Exposure: structured questionnaire assessed by an environmental hygienist about work held > 6 mos | 8 exposed cases (5%)—2 women, 1 man; 5 exposed controls (3%)—3 women, 2 men; OR = 1.7 (0.4–7.6) |
SSc: systemic sclerosis. OR: odds ratio. Modified from Parks, et al54.