Table 1.

Variables and domains reported in previous studies of flare in rheumatoid arthritis.

VariableNo. of Studies in which variable/domain was usedReferences
Tender joint count138, 10, 11, 12, 13, 14, 15, 19, 20, 21, 22, 36, 37
Swollen joint count138, 10, 11, 12, 13, 14, 15, 19, 20, 21, 22, 36, 37
Patient global assessment108, 10, 11, 14, 15, 19, 20, 21, 22, 36
Erythrocyte sedimentation rate1010, 11, 13, 14, 15, 16, 19, 20, 22, 36
Patient assessment of pain78, 10, 11, 12, 13, 17, 22
Disease Activity Score714, 15, 18, 19, 20, 22, 36
C-reactive protein610, 12, 15, 16, 20, 22
Health Assessment Questionnaire610, 11, 12, 15, 20, 22
Physician global assessment58, 10, 11, 21, 22
Fatigue313, 17, 22
Physician assessment of pain28, 22
Morning stiffness213, 22
Ritchie Articular Index213, 22
ARA functional class28, 22
Synovitis213, 22
Van der Heijde modified Sharp Score215, 22
Complete blood count, liver enzymes, creatinine, radiographs216, 22
Bone absorptiometry216, 22
RADAI score219, 22
Change in patient global assessment122
Grip strength122
50 foot walk time122
  • ARA: American Rheumatology Association; RADAI: rheumatoid arthritis disease activity index.