Table 5.

Interaction between STAT4 and TNFRSF1B genotypes.

STAT4 rs7574865+ TNFRSF1B rs 1061622OR (95% CI)
CrudepAdjusted*p
rs7574865 GG + rs1061622 TT1.0 (reference)1.0 (reference)
rs7574865 GG + rs1061622 G carrier1.73 (0.93–3.20)0.0811.89 (0.94–3.81)0.076
rs7574865 T carrier + rs1061622 TT1.67 (1.05–2.65)0.0301.61 (0.95–2.74)0.076
rs7574865 T carrier + rs1061622 G carrier2.20 (1.27–3.81)0.0052.14 (1.13–4.05)0.020
Multiplicative interaction measure0.76 (0.34–1.71)0.5080.70 (0.27–1.77)0.453
Additive interaction measure
  Relative excess due to interaction–0.19 (−1.62 to 1.24)0.794–0.35 (−2.06 to 1.36)0.688
  Attributable proportion due to interaction–0.09 (−0.76 to 0.58)0.492–0.16 (−0.99 to 0.67)0.706
  Synergy index0.86 (0.29 to 2.56)0.7860.77 (0.22 to 2.70)0.682
  • * Adjusted for age, region, and alcohol intake.