Table 4.

Interaction between smoking and TNFRSF1B rs1061622 genotypes.

OR (95% CI)
CrudepAdjusted*p
TT genotype + nonsmoking1.0 (reference)1.0 (reference)
TT genotype + smoking1.92 (1.16–3.17)0.0112.39 (1.36–4.23)0.003
G allele carrier + nonsmoking1.38 (0.85–2.23)0.1861.33 (0.77–2.32)0.307
G allele carrier + smoking3.42 (1.73–6.74)< 0.00015.42 (2.48–11.84)< 0.0001
Multiplicative interaction measure1.29 (0.53–3.14)0.5761.70 (0.62–4.61)0.300
Additive interaction measure
  Relative excess due to interaction1.12 (−1.205 to 3.44)0.3452.65 (−1.35 to 6.65)0.194
  Attributable proportion due to interaction0.33 (−0.18 to 0.84)0.2050.49 (0.07–0.92)0.023
  Synergy index1.87 (0.57–6.21)0.3042.54 (0.80–8.09)0.114
  • * Adjusted for age, region, and alcohol intake.