Interaction between smoking and STAT4 genotypes.
| OR (95% CI) | ||||
|---|---|---|---|---|
| Crude | p | Adjusted* | p | |
| GG genotype + nonsmoking | 1.0 (reference) | 1.0 (reference) | ||
| GG genotype + smoking | 2.09 (1.13–3.85) | 0.017 | 2.65 (1.35–5.21) | 0.005 |
| T allele carrier + nonsmoking | 1.52 (0.96–2.41) | 0.072 | 1.36 (0.81–2.30) | 0.248 |
| T allele carrier + smoking | 3.45 (1.90–6.24) | < 0.0001 | 4.37 (2.22–8.62) | < 0.0001 |
| Multiplicative interaction measure | 1.08 (0.47–2.47) | 0.854 | 1.21 (0.48–3.3) | 0.681 |
| Additive interaction measure | ||||
| Relative excess due to interaction | 0.83 (−1.15 to 2.82) | 0.412 | 1.37 (−1.46 to 4.20) | 0.343 |
| Attributable proportion due to interaction | 0.24 (−0.26 to 0.74) | 0.347 | 0.31 (−0.20 to 0.82) | 0.234 |
| Synergy index | 1.53 (0.55 to 4.24) | 0.414 | 1.66 (0.59 to 4.65) | 0.336 |
↵* Adjusted for age, region, and alcohol intake.