Table 2.

Reasons for discontinuation of the second TNF blocking agent at 3 and 6 months and the total followup time.

TimepointNonresponse (A) n = 49Loss of Response (B) n = 75Adverse Events (C) n = 73
3 months
  Lack of effect (%)2/5 (40)1/8 (13)
  Adverse events (%)2/2 (100)3/5 (60)7/8 (88)
  Other (%)
6 months
  Lack of effect (%)4/6 (67)10/16 (63)4/17 (24)
  Adverse events (%)2/6 (33)6/16 (38)12/17 (71)
  Other (%)*1/17 (6)
Total followup time
  Lack of effect (%)13/20 (65)20/30 (67)7/26 (27)
  Adverse events (%)5/20 (25)9/30 (30)15/26 (58)
  Other (%)**2/20 (10)1/30 (3)4/26 (15)
  • * Patient’s own initiative.

  • ** In group A 1 patient died and 1 patient discontinued due to planned surgery; in group B 1 patient discontinued because of wish for pregnancy; in group C 3 patients discontinued on their own initiative and 1 patient was lost to followup.