Results of family-based case-control analysis of IL9R (rs3093457, minor allele C).
| Set 1 | Set 1 & 2 | Set 1 & 2 & 3 | |
|---|---|---|---|
| No. of cases | 89 | 180 | 437 |
| Homozygous minor genotype vs others (Lathrop) p value | 0.028 | 0.020 | 0.056 |
| Minor allele GRR (95% CI) | 2.34 (1.1–5) | 1.96 (1.2–3.4) | 1.46 (1–2.1) |
| Set 1, male | Set 1 & 2, male | Set 1 & 2 & 3, male | |
| No. of cases | 12 | 20 | 55 |
| Homozygous minor genotype vs others (Lathrop) p value | 0.013 | 0.005 | 0.01 |
| Minor allele GRR (95% CI) | 15.49 (1.8–130.9) | 11.23 (2.1–60) | 3.75 (1.4–10.2) |
| Set 1, a-CCP+ | Set 1 & 2, a-CCP+ | Set 1 & 2 & 3, a-CCP+ | |
| No. of cases | 68 | 132 | 209 |
| Homozygous minor genotype vs others (Lathrop) p value | 0.019 | 0.008 | 0.037 |
| Minor allele GRR (95% CI) | 2.71 (1.2–6.2) | 2.33 (1.2–4.3) | 1.76 (1–3) |
GGR: genetic relative risk; male subgroup: family trios with male patients; a-CCP+: subgroup positive for anti-cyclic citrullinated peptide antibodies, i.e., family trios with anti-CCP-positive patients.