Results of family-trio TDT analysis for TIMP1 (rs6020277, minor allele C; rs6520278, minor allele T). Minor allele transmissions (no. of transmitted alleles: untransmitted alleles) are shown.
| rs6520277 | Set 1, male | Set 1 & 2, male | Set 1 & 2 & 3, male |
|---|---|---|---|
| No. of families | 6 | 9 | NI |
| Minor allele transmission | 0:6 | 1:8 | NI |
| TDT p value | 0.014 | 0.020 | NI |
| rs6520278 | Set 1 | Set 1 & 2 | Set 1 & 2 & 3 |
| No. of informative families | 45 | 78 | 189 |
| Minor allele transmission | 15:30 | 29:49 | 80:109 |
| TDT p value | 0.025 | 0.024 | 0.035 |
| rs6520278 | Set 1, male | Set 1 & 2, male | Set 1 & 2 & 3, male |
| No. of informative families | 7 | 9 | 21 |
| Minor allele transmission | 0:7 | 1:8 | 9:12 |
| TDT p value | 0.008 | 0.020 | 0.513 |
Male subgroup: family trios with male patients. NI: not investigated.