Risk of organ involvement in SSc. Age of SSc onset are modeled as both dichotomous and continuous variables in logistic regression.
| Outcome | Age at Onset† Modeled As Dichotomous Variable OR (95% CI) | Age at Onset† Modeled As Continuous Variable†† OR (95% CI) |
|---|---|---|
| Pulmonary hypertension (right heart catheterization), n = 2300 | ||
| Unadjusted | 1.23 (0.75, 2.03) | 1.09 (0.98, 1.22) |
| Adjusted* | 1.76 (1.00, 3.12) | 1.34 (1.17, 1.54) |
| Pulmonary hypertension (echocardiogram or right heart catheterization), n = 2300 | ||
| Unadjusted | 1.89 (1.42, 2.52) | 1.25 (1.17, 1.33) |
| Adjusted* | 3.28 (2.34, 4.60) | 1.66 (1.52, 1.81) |
| Restrictive lung disease (FVC < 70%): among nonobstructed, n = 1568 | ||
| Unadjusted | 0.69 (0.47, 1.00) | 0.95 (0.88, 1.02) |
| Adjusted** | 0.80 (0.54, 1.19) | 1.01 (0.93, 1.09) |
| Cardiac disease, n = 1991 | ||
| Unadjusted | 1.93 (1.40, 2.66) | 1.30 (1.21, 1.40) |
| Adjusted** | 2.69 (1.92, 3.78) | 1.60 (1.46, 1.75) |
| Muscle weakness, n = 1976 | ||
| Unadjusted | 1.57 (1.12, 2.20) | 1.09 (1.01, 1.17) |
| Adjusted§ | 1.85 (1.30, 1.64) | 1.14 (1.05, 1.23) |
| Digital ischemia, n = 2286 | ||
| Unadjusted | 0.45 (0.34, 0.61) | 0.75 (0.71, 0.80) |
| Adjusted** | 0.64 (0.47, 0.86) | 0.82 (0.76, 0.87) |
| Severe gastrointestinal involvement, n = 1153 | ||
| Unadjusted | 0.46 (0.29, 0.72) | 0.92 (0.83, 1.02) |
| Adjusted§ | 0.80 (0.49, 1.30) | 1.11 (0.99, 1.25) |
| Renal impairment, n = 2022 | ||
| Unadjusted | 2.28 (1.63, 3.19) | 1.27 (1.17, 1.38) |
| Adjusted§ | 2.83 (1.98, 4.04) | 1.41 (1.28, 1.55) |
↵† SSc onset defined as age of first non-Raynaud’s phenomenon SSc symptom.
↵†† Age at onset per 10 years.
↵* Adjusted for race, sex, subtype, disease duration and FVC.
↵** Adjusted for race, sex, subtype, disease duration, and smoking status.
↵§ Adjusted for race, sex, subtype, and disease duration. SSc: systemic sclerosis; FVC: forced vital capacity