Characteristics of patients with TRAPS-like syndrome: clinical features and functional cellular defects and genotypes at the TNFRSF1A and other candidate gene loci.
| Characteristic | Patient | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| Sex | M | F | F | M | M |
| Age, yrs | 43 | 24 | 30 | 22 | 32 |
| Disease onset, yrs | 15.0 | 2.0 | 5.0 | 2 | 9 |
| Duration of fever episodes, days | 25.0 | 22.5 | 6.0 | 20 | 7 |
| Frequency, episodes/yr | 2 | 3 | 4 | 3 | 4 |
| Abdominal pain | ++ | + | ++ | + | + |
| Arthritis/arthralgia | + | + | ++ | ++ | ++ |
| Rash | − | + | − | ++ | − |
| Ocular manifestations† | − | + | − | − | − |
| Treatment | CS, NSAID | CS, NSAID | CS, NSAID, anakinra | CS, NSAID | CS, NSAID |
↵† Periorbital edema in Patient 2. CS: corticosteroids on demand; NSAID: nonsteroidal antiinflammatory drugs.