Diagnostic value of the 3 criteria sets (unmodified ACR 1987, modified ACR 1987 criteria, and more than 6 points on the ACR/EULAR score), and of the best combination of items in the Brittany cohort in the overall population, in the subgroup meeting the 3 conditions for ACR/EULAR scoring (synovitis, no better alternative diagnosis, and no radiographic erosion typical for RA), and in the overall population classified according to the full ACR/EULAR tree.
| Criteria | Subgroups | Sensitivity, % (95% CI) | Specificity, % (95% CI) | Positive Predictive Value, (95% CI) | Negative Predictive Value, (95% CI) | AUC* |
|---|---|---|---|---|---|---|
| ACR 1987 criteria, ≥ 4 | Overall | 64/100, 64 (53.7–73.2) | 136/170, 80 (73.0–85.6) | 64/98, 65.3 (54.9–74.4) | 136/172, 79.1 (72.1–84.71) | 0.81 |
| Conditions met | 50/78, 64.1 (52.4–74.4) | 43/65, 66.1 (53.2–77.1) | 50/72, 69.4 (58.4–79.5) | 43/71, 60.6 (48.2–71.7) | 0.74 | |
| Full tree | 61/100, 61 (50.7–70.4) | 151/170, 88.8 (82.9–92.9) | 61/88, 69.3 (58.4–78.5) | 143/182, 78.6 (71.8–84.1) | ||
| ACR 1987 criteria with Liao 2 modification, ≥ 3 | Overall | 69/100, 69 (58.9–77.7) | 136/170, 80 (73.3–85.6) | 69/98, 70.4 (60.2–78.9) | 136/172, 79.1 (72.1–84.7) | 0.81 |
| Conditions met | 67/78, 85.9 (75.7–92.4) | 36/65, 55.4 (42.6–67.5) | 67/96, 69.8 (59.5–78.5) | 36/47, 76.6 (61.6–87.2) | 0.77 | |
| Full tree | 72/100, 72 (61.9–80.3) | 144/170, 84.7 (78.2–89.6) | 78/112, 69.6 (60.1–77.8) | 136/158, 86.1 (79.5–90.9) | ||
| ACR 1987 criteria with Liao 1 modification, ≥ 4 | Overall | 84/100, 84 (75.0–90.3) | 112/170, 65.9 (58.2–72.9) | 84/142, 59.1 (50.6–67.2) | 112/128, 87.5 (80.2–92.5) | 0.83 |
| Conditions met | 54/78, 69.2 (57.6–78.9) | 43/65, 66.1 (53.2–77.1) | 54/76, 71.0 (59.3–80.6) | 43/67, 64.2 (51.5–75.3) | 0.77 | |
| Full tree | 65/100, 65 (54.7–74.1) | 143/170, 84.1 (77.5–89.1) | 65/92, 70.6 (60.1–79.4) | 143/178, 80.3 (73.6–85.8) | ||
| ACR/EULAR score ≥ 6 | Overall | 58/100, 58 (47.7–67.7) | 143/170, 85.9 (79.5–90.6) | 58/82, 70.7 (59.5–79.9) | 146/188, 77.6 (70.9–83.3) | 0.83 |
| Conditions met | 40/78, 51.3 (39.8–62.7) | 53/65, 81.5 (69.6–89.7) | 40/52, 76.9 (62.8–87) | 53/91, 58.2 (47.4–68.3) | 0.78 | |
| Full tree | 51/100, 51 (40.9–61.1) | 153/170, 90 (84.2–93.9) | 51/68, 75 (84.2–93.9) | 153/202, 75.7 (69.1–81.4) | ||
| Best combination of items in the Brittany cohort ≥ 5 | Overall | 62/100, 62 (51.7–71.4) | 145/170, 85.3 (78.9–90.1) | 62/87, 71.3 (60.4–80.2) | 145/183, 79.2 (72.5–84.7) | 0.84 |
| Conditions met | 50/78, 64.1 (52.4–74.4) | 53/65, 81.8 (69.6–89.7) | 50/62, 80.6 (68.2–89.2) | 53/81, 65.4 (53.9–75.4) | 0.83** | |
| Full tree | 61/100, 61 (50.7–70.4) | 153/170, 90 (84.2–93.9) | 61/88, 69.3 (58.4–78.5) | 153/192, 79.7 (73.2–84.9) |