TNF-α Inhibitor Therapy, n = 23 New Syndesmophytes at Followup | p* | Standard Therapy, n = 27 New Syndesmophytes at Followup | p* | |||
---|---|---|---|---|---|---|
Yes | No | Yes | No | |||
Concordant Reads | ||||||
Baseline MRI | ||||||
Vertebral corner with CIL | 3 (16.7) | 15 (83.3) | 0.01† | 3 (15.0) | 17 (85.0)† | 0.03† |
Vertebral corner without CIL | 7 (2.2) | 300 (97.7) | 16 (3.2) | 478 (96.8) | ||
Followup MRI | ||||||
Completely resolved CIL | 3 (42.9) | 4 (57.1) | 0.0009†† | 1 (20.0) | 4 (80.0)†† | 0.16†† |
Persistent CIL | 0(0) | 4 (100) | 0.76** | 0 (0) | 10 (100) | 0.56** |
No CIL | 7 (2.4) | 287 (97.6) | 16 (3.3) | 469 (96.7) | ||
New CIL at followup | 1 | 3 | ||||
First reads | ||||||
Baseline MRI | ||||||
Vertebral corner with CIL | 4 (7.5) | 49 (92.5) | 0.08† | 3 (5.8) | 49 (94.2)† | 0.43† |
Vertebral corner without CIL | 8 (2.5) | 312 (97.5) | 16 (3.2) | 488 (96.8) | ||
Followup MRI | ||||||
Completely resolved CIL | 4 (15.4) | 22 (84.6) | 0.009†† | 2 (10.6) | 17 (89.5)†† | 0.14†† |
Persistent CIL | 0 (0) | 27 (100) | 0.40** | 1 (3.0) | 32 (97.0)** | 0.95** |
No CIL | 8 (2.6) | 303 (97.4) | 16 (3.2) | 481 (96.8) | ||
New CIL at followup | 9 | 7 | ||||
Second reads | ||||||
Baseline MRI | ||||||
Vertebral corner with CIL | 4 (12.9) | 27 (87.1) | 0.01† | 3 (10.0) | 27 (90.0) | 0.08† |
Vertebral corner without CIL | 8 (2.3) | 334 (97.7) | 16 (3.0) | 510 (97.0) | ||
Followup MRI | ||||||
Completely resolved CIL | 4 (15.4) | 22 (84.6) | 0.007†† | 2 (11.1) | 16 (88.9) | 0.12†† |
Persistent CIL | 0 (0) | 5 (100) | 0.73** | 1 (7.6) | 12 (92.3) | 0.35** |
No CIL | 8 (2.4) | 327 (97.6) | 16 (3.1) | 502 (96.9) | ||
New CIL at followup | 7 | 7 |
↵* Pearson chi-squared test.
↵† Compared to vertebral corners without a CIL baseline.
↵†† Comparison of new syndesmophytes developing in vertebral corners with a CIL that has completely resolved on followup MRI vs those vertebral corners with no CIL on either baseline or followup MRI scan.
↵** Comparison of new syndesmophytes developing in vertebral corners with a CIL that is present on both baseline and followup MRI vs those vertebral corners where there is no CIL on either MRI scan. CIL: corner inflammatory lesions; MRI: magnetic resonance imaging; TNF-α: tumor necrosis factor-α. Reader 1: PC; Reader 2: SJP; standard therapy included NSAID and physical therapy.