Clinical presentation and histology results of patients with inflammatory bowel disease (IBD). Patient 3 had the first IBD disease episode (3a) prior to and a relapse (3b) after restarting etanercept.
| Patient | Type of IBD | Abdominal Pain | Aspect of Stool | Frequency of Stool | Weight Loss | Other Symptoms | Endoscopy | Pathology |
|---|---|---|---|---|---|---|---|---|
| 1 | UC | + | D, B, M | 4/day | 2.8 kg in 3 mo | Vomiting | Grade II-III proctosigmoiditis | Colon: active infection, crypt abscess, changed architecture indicative of UC |
| 2 | CD | + | D, B, M | 6/day | 4 kg in 1 mo | More arthritis, Perianal abscess | Skip lesions | Indeterminate, later CD |
| 3a | CD | + | D, B | 2–8/day | 5 kg in 3 mo | Vomiting and fatigue | Normal | Colon: UC or CD with inflammation, granulomas |
| 3b | CD | ++ | D | 6/day | NA | Abdominal cramps, pancreatitis | NA | |
| 4 | CD | – | – | 1/day | No | Raised ESR and CRP; erythema nodosum | NA | Esophagitis: with epitheloid cell reaction and isolated giant cells Duodenitis: with microgranulomata Colitis with epitheloid cell reaction |
| 5 | CD | + | NA | NA | NA | No | NA | CD |
| 6 | UC | + | D, B | 25/day | No | No | Ulcers, terminal ilium normal | Colitis with crypt abscess and ulcers, no granulomas |
| 7 | CD | + | D, B | 6/day | No | No | NA | CD |
| 8 | CD | + | D | NA | No | NA | NA | Overall active CD with granulomas |
| 9 | CD | + | D | 5/day | Yes | Anemia | CD | CD |
| 10 | CD | + | D | 3/day | Yes | Unknown | NA | CD |
| 11 | ID | + | D | 3/day | Growth stop, 1 yr | No | Chronic inflammation; colitis with crypt abscess | |
| 12 | CD | + | D | 2/day | 6.5 kg in 3 mo | No | CD | CD |
| 13 | UC | + | D, B | > 3 x/day | 6 kg in 7 mo | No | NA | UC |
D: diarrhea, B: blood, M: mucus, CD: Crohn’s disease; UC: ulcerative colitis; ID: indeterminate; NA: not available.