TY - JOUR T1 - Severe systemic hypersensitivity reaction to ibuprofen: a presentation of systemic lupus erythematosus. JF - The Journal of Rheumatology JO - J Rheumatol SP - 171 LP - 172 VL - 33 IS - 1 AU - Steven S Mou AU - Lynn Punaro AU - Jordi Antón AU - Peter M Luckett Y1 - 2006/01/01 UR - http://www.jrheum.org/content/33/1/171.abstract N2 - We describe the first severe systemic hypersensitivity reaction to ibuprofen in a pediatric patient with previously undiagnosed systemic lupus erythematosus (SLE). An 11-year-old Thai male presented with fever, rash, altered mental status, and hypotension after oral administration of ibuprofen leading to the diagnosis of SLE. Re-dosing with ibuprofen resulted in recurrence of presenting symptoms. Severe hypersensitivity with hypotension can be a rare consequence of the use of ibuprofen in children with collagen vascular disease. When encountered in an otherwise healthy child, a high index of suspicion must be maintained for the diagnosis of SLE. ER -