PT  - JOURNAL ARTICLE
AU  - Steven S Mou
AU  - Lynn Punaro
AU  - Jordi Antón
AU  - Peter M Luckett
TI  - Severe systemic hypersensitivity reaction to ibuprofen: a presentation of systemic lupus erythematosus.
DP  - 2006 Jan 01
TA  - The Journal of Rheumatology
PG  - 171--172
VI  - 33
IP  - 1
4099  - http://www.jrheum.org/content/33/1/171.short
4100  - http://www.jrheum.org/content/33/1/171.full
SO  - J Rheumatol2006 Jan 01; 33
AB  - We describe the first severe systemic hypersensitivity reaction to ibuprofen in a pediatric patient with previously undiagnosed systemic lupus erythematosus (SLE). An 11-year-old Thai male presented with fever, rash, altered mental status, and hypotension after oral administration of ibuprofen leading to the diagnosis of SLE. Re-dosing with ibuprofen resulted in recurrence of presenting symptoms. Severe hypersensitivity with hypotension can be a rare consequence of the use of ibuprofen in children with collagen vascular disease. When encountered in an otherwise healthy child, a high index of suspicion must be maintained for the diagnosis of SLE.