RT Journal Article
SR Electronic
T1 Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2085
OP 2087
VO 33
IS 10
A1 Metyas, Samy K
A1 Hoffman, Hal M
YR 2006
UL http://www.jrheum.org/content/33/10/2085.abstract
AB OBJECTIVE: Familial cold autoinflammatory syndrome (FCAS) is a rare, hereditary disorder characterized by cold-induced inflammation. We describe the successful longterm treatment of a patient with FCAS with anakinra, an interleukin 1 receptor antagonist (IL-1Ra). The remarkable response of FCAS and associated Raynaud's disease in this patient suggests that IL-1 is an important mediator of these inflammatory diseases. Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases.