PT  - JOURNAL ARTICLE
AU  - Metyas, Samy K
AU  - Hoffman, Hal M
TI  - Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease.
DP  - 2006 Oct 01
TA  - The Journal of Rheumatology
PG  - 2085--2087
VI  - 33
IP  - 10
4099  - http://www.jrheum.org/content/33/10/2085.short
4100  - http://www.jrheum.org/content/33/10/2085.full
SO  - J Rheumatol2006 Oct 01; 33
AB  - OBJECTIVE: Familial cold autoinflammatory syndrome (FCAS) is a rare, hereditary disorder characterized by cold-induced inflammation. We describe the successful longterm treatment of a patient with FCAS with anakinra, an interleukin 1 receptor antagonist (IL-1Ra). The remarkable response of FCAS and associated Raynaud's disease in this patient suggests that IL-1 is an important mediator of these inflammatory diseases. Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases.