TY - JOUR T1 - Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus. JF - The Journal of Rheumatology JO - J Rheumatol SP - 1843 LP - 1845 VL - 32 IS - 9 AU - Shyam Prabhakaran AU - Matthew Bramlage AU - Mark A Edgar AU - Betty Diamond AU - John A Hardin AU - Bruce T Volpe Y1 - 2005/09/01 UR - http://www.jrheum.org/content/32/9/1843.abstract N2 - We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus. ER -