PT  - JOURNAL ARTICLE
AU  - Hang-Korng Ea
AU  - Anne Blanchard
AU  - Maxime Dougados
AU  - Christian Roux
TI  - Chondrocalcinosis secondary to hypomagnesemia in Gitelman's syndrome.
DP  - 2005 Sep 01
TA  - The Journal of Rheumatology
PG  - 1840--1842
VI  - 32
IP  - 9
4099  - http://www.jrheum.org/content/32/9/1840.short
4100  - http://www.jrheum.org/content/32/9/1840.full
SO  - J Rheumatol2005 Sep 01; 32
AB  - Chondrocalcinosis can be associated with hyperparathyroidism, hemochromatosis, hypophosphatasia, and hypomagnesemia. Gitelman syndrome (GS), an inherited disorder due to loss of function mutations of the gene encoding the distal convoluted tubule Na-Cl cotransporter (NCCT), is characterized by hypokalemia metabolic alkalosis, hypomagnesemia, and hypocalciuria. A 53-year-old man, with history of recurrent joint effusions and pains affecting knees and wrists, had transient episodes of muscle pain, weakness, cramping, and fatigue over a one-year period. Laboratory tests showed hypokalemia, metabolic alkalosis, hypocalciuria, and hypomagnesemia related to genetically proven GS. Radiographs of affected joints revealed calcium pyrophosphate dihydrate deposition. This observation points out the necessity to look for Mg depletion (and especially GS) in the biological investigation of chondrocalcinosis. Additionally, the association between GS (NCCT inactivation) and high bone mineral density provides a new insight into the possible role of thiazides in osteoporosis management.