<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Satoh, Takashi</style></author><author><style face="normal" font="default" size="100%">Okano, Tetsuroh</style></author><author><style face="normal" font="default" size="100%">Matsui, Toshimichi</style></author><author><style face="normal" font="default" size="100%">Watabe, Hiroyuki</style></author><author><style face="normal" font="default" size="100%">Ogasawara, Takashi</style></author><author><style face="normal" font="default" size="100%">Kubo, Kouya</style></author><author><style face="normal" font="default" size="100%">Kuwana, Masataka</style></author><author><style face="normal" font="default" size="100%">Fertig, Noreen</style></author><author><style face="normal" font="default" size="100%">Oddis, Chester V</style></author><author><style face="normal" font="default" size="100%">Kondo, Hirobumi</style></author><author><style face="normal" font="default" size="100%">Akahoshi, Tohru</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel autoantibodies against 7SL RNA in patients with polymyositis/dermatomyositis.</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Rheumatology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2005-09-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1727-1733</style></pages><volume><style face="normal" font="default" size="100%">32</style></volume><issue><style face="normal" font="default" size="100%">9</style></issue><abstract><style  face="normal" font="default" size="100%">OBJECTIVE: Autoantibodies against signal recognition particle (SRP) are detected in patients with polymyositis/dermatomyositis (PM/DM). The SRP consists of 7SL RNA and 6 protein components. We examined autoantibodies against deproteinized 7SL RNA in PM/DM patients with anti-SRP antibodies and evaluated the association of anti-7SL RNA antibodies with PM/DM clinically and serologically. METHODS: Sera from 10 Japanese and 22 North American PM/DM patients with anti-SRP antibodies were tested for the presence of anti-7SL RNA antibodies, using the sera to immunoprecipitate deproteinized RNA extracts derived from HeLa cells. RESULTS: The immunoprecipitation analysis indicated that 5 Japanese (50%) and one North American (5%) patient with anti-SRP antibodies had novel autoantibodies against deproteinized 7SL RNA. The frequency of anti-7SL RNA antibodies was significantly higher in Japanese than North American patients (p = 0.006). The presence of anti-7SL RNA antibodies appeared to be associated with DM (2 patients) and finger swelling (2 PM patients). The seasonal onset of the disease was different (p = 0.008) for Japanese PM/DM patients with anti-7SL RNA antibodies, who developed the disease between October and January (mean month November; p = 0.01) from that of patients without these antibodies, who developed it between June and August (mean month July; p = 0.01). CONCLUSION: Novel autoantibodies against 7SL RNA were identified in patients with PM/DM, and the presence of these antibodies was correlated to ethnic background, clinical features, and season of disease onset. These findings indicated that autoantibodies against 7SL RNA are a novel serological marker for a subset of PM/DM cases.</style></abstract></record></records></xml>