@article {Adachi1615, author = {Nobuo Adachi and Mitsuo Ochi and Masataka Deie and Yohei Ito}, title = {Transplant of mesenchymal stem cells and hydroxyapatite ceramics to treat severe osteochondral damage after septic arthritis of the knee.}, volume = {32}, number = {8}, pages = {1615--1618}, year = {2005}, publisher = {The Journal of Rheumatology}, abstract = {We describe a 21-year-old man with a large osteochondral defect of the knee after septic arthritis, successfully treated by transplant of mesenchymal stem cells (MSC) from bone marrow and a new type of interconnected porous hydroxyapatite ceramic (IP-CHA). We confirmed successful cartilage-like tissue regeneration by a second arthroscopy. Biopsy of the repaired tissue revealed cartilage-like regeneration and bone formation. We were able to regenerate new bone and cartilage-like tissue in a one-stage operation, without sacrificing autologous bone or other tissue. This cultured MSC and IP-CHA hybrid material transplant represents a novel treatment for a severe osteochondral defect after septic arthritis.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/32/8/1615}, eprint = {https://www.jrheum.org/content/32/8/1615.full.pdf}, journal = {The Journal of Rheumatology} }