RT Journal Article
SR Electronic
T1 Response to a urate-lowering diet according to polymorphisms in the apolipoprotein AI-CIII-AIV cluster.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 903
OP 905
VO 32
IS 5
A1 Fernando Cardona
A1 Francisco J Tinahones
A1 Eduardo Collantes
A1 Eduardo Garcia-Fuentes
A1 Alejandro Escudero
A1 Federico Soriguer
YR 2005
UL http://www.jrheum.org/content/32/5/903.abstract
AB OBJECTIVE: The apolipoprotein AI-CIII-AIV cluster has been associated with the response to a urate-lowering diet, and polymorphisms in the apolipoprotein CIII gene have been associated with hyperuricemia and hypertriglyceridemia. We assessed the influence of polymorphisms in the apolipoprotein AI-CIII-AIV cluster on the response to a urate-lowering diet in patients with hyperuricemia. METHODS: A urate-lowering diet was followed for 2 weeks by 64 men with hyperuricemia. Plasma concentrations of triglycerides, cholesterol, glucose, and uric acid, and the uric acid clearance and 24-hour uric acid urinary excretory fraction were measured before and after the diet. The data were analyzed in association with the polymorphisms of the apolipoprotein AI-CIII-AIV gene cluster. RESULTS: After the urate-lowering diet, the plasma levels of triglycerides, cholesterol, glucose, and uric acid and 24-hour uric acid excretion all fell significantly. Paired sample ANOVA showed that the decrease was mainly due to the diet, except for the plasma triglycerides, which were influenced by allele X2 of the XmnI polymorphism of the apolipoprotein AI gene. CONCLUSION: The response of the biological variables to a urate-lowering diet was mainly influenced by diet. Changes in triglycerides were also influenced by the apolipoprotein AI XmnI polymorphism (p = 0.04), suggesting a gene-diet interaction (p = 0.03).