RT Journal Article
SR Electronic
T1 HLA-B27 associated spondyloarthropathy, vasculitis, and amyloid enteropathy: response to infliximab.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 382
OP 385
VO 32
IS 2
A1 Lisa K Stamp
A1 John L O'Donnell
YR 2005
UL http://www.jrheum.org/content/32/2/382.abstract
AB In 2000 we described a patient with HLA-B27 associated spondyloarthropathy (SpA) and severe ascending aortitis requiring surgical intervention. Despite continued immunosuppressive therapy she developed narrowing of the distal part of the right subclavian artery and proximal axillary artery secondary to active vasculitis. In addition, biopsy-proven amyloid gastroenteropathy developed causing persistent diarrhea and iron deficiency anemia. Treatment with infliximab resulted in resolution of joint symptoms and rapid improvement in laboratory markers of inflammation. Diarrhea settled more gradually, such that her bowel habit had normalized 16 months after therapy commenced.