PT  - JOURNAL ARTICLE
AU  - Amoli, Mahsa M
AU  - Garcia-Porrua, Carlos
AU  - Ollier, William E R
AU  - Gonzalez-Gay, Miguel A
TI  - Lack of association between macrophage migration inhibitory factor gene polymorphism and giant cell arteritis.
DP  - 2005 Jan 01
TA  - The Journal of Rheumatology
PG  - 74--76
VI  - 32
IP  - 1
4099  - http://www.jrheum.org/content/32/1/74.short
4100  - http://www.jrheum.org/content/32/1/74.full
SO  - J Rheumatol2005 Jan 01; 32
AB  - OBJECTIVE: To investigate the role of macrophage migration inhibitory factor (MIF) gene polymorphism in giant cell arteritis (GCA). METHODS: Eighty-three patients with biopsy-proven GCA, 20 of them with visual ischemic complications, and 122 healthy matched controls from the Lugo region of Northwest Spain were studied. Patients and controls were genotyped for a single nucleotide polymorphism in the 5'-flanking region at position -173 of the MIF gene, using SNapshot ddNTP primer extension, followed by capillary electrophoresis (ABI 3100). RESULTS: No significant differences in MIF gene polymorphism were observed in patients with biopsy-proven GCA compared to controls. This was also the case when GCA patients with or without visual ischemic complications were compared. CONCLUSION: Polymorphism in MIF gene promoter -173 G/C does not appear to be a genetic risk factor for GCA in Northwest Spain.