RT Journal Article
SR Electronic
T1 Current status of outcome measures in vasculitis: focus on Wegener's granulomatosis and microscopic polyangiitis. Report from OMERACT 7.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2488
OP 2495
VO 32
IS 12
A1 Peter A Merkel
A1 Philip Seo
A1 Peter Aries
A1 Tuhina Neogi
A1 Alexandra Villa-Forte
A1 Maarten Boers
A1 David Cuthbertson
A1 David T Felson
A1 Bernhard Hellmich
A1 Gary S Hoffman
A1 David R Jayne
A1 Cees G M Kallenberg
A1 Jeffrey Krischer
A1 Alfred Mahr
A1 Eric L Matteson
A1 Ulrich Specks
A1 Raashid Luqmani
A1 John Stone
A1 Vasculitis Clinical Research Consortium
A1 OMERACT 7 Special Interest Group
YR 2005
UL http://www.jrheum.org/content/32/12/2488.abstract
AB The complexity of assessing disease activity, disease status, and damage in the vasculitides reflects the multisystemic pathologic manifestations of these often chronic illnesses. Major progress has been made in the past decade in the development of validated and widely accepted outcome measures for use in clinical trials. Over time, these tools have been regularly revised, expanded, and supplemented with new measures of disease prognosis and damage. As a result clinical research in this area has become increasingly complex. This article critically reviews the current status of tools for assessing disease activity and damage in "ANCA-associated" vasculitides (Wegener's granulomatosis and microscopic polyangiitis), summarizes the current level of validation of each measure, addresses central problems and controversies to be considered during development of new vasculitis assessment tools, and proposes a series of research agendas for consideration by the vasculitis research community.