RT Journal Article
SR Electronic
T1 Synovial tissue analysis in clinical trials.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2481
OP 2484
VO 32
IS 12
A1 Barry Bresnihan
A1 Dominique Baeten
A1 Gary S Firestein
A1 Oliver M Fitzgerald
A1 Danielle M Gerlag
A1 Jasper J Haringman
A1 Iain B McInnes
A1 Richard J Reece
A1 Malcolm D Smith
A1 Ann-Kristin Ulfgren
A1 Douglas J Veale
A1 Paul Peter Tak
A1 OMERACT 7 Special Interest Group
YR 2005
UL http://www.jrheum.org/content/32/12/2481.abstract
AB Synovial tissue analysis has considerable potential for future randomized controlled trials (RCT). The synovial membrane is the target tissue in treatment strategies of rheumatoid arthritis and other arthropathies. Effective modulation of synovitis is critical when attempting to control symptoms and signs, to prevent joint damage, and to maintain function. In RCT, the systematic evaluation of changes in synovial tissue after commencing treatment enables identification of an early therapeutic effect, using relatively small numbers of patients. This special interest group is working on establishing the evidence to have this endpoint meet the OMERACT filter criteria.