PT  - JOURNAL ARTICLE
AU  - Christopher Lee Colglazier
AU  - Paul G Sutej
AU  - Kenneth S O'Rourke
TI  - Severe refractory fingertip ulcerations in a patient with scleroderma: successful treatment with sildenafil.
DP  - 2005 Dec 01
TA  - The Journal of Rheumatology
PG  - 2440--2442
VI  - 32
IP  - 12
4099  - http://www.jrheum.org/content/32/12/2440.short
4100  - http://www.jrheum.org/content/32/12/2440.full
SO  - J Rheumatol2005 Dec 01; 32
AB  - Systemic sclerosis (scleroderma) is a multisystem fibrotic disease that commonly manifests with severe Raynaud's phenomenon and slow-healing cutaneous ulcerations. Reduced nitric oxide levels have been proposed to play a role in the pathogenesis of vascular disease in scleroderma, and therefore sildenafil (which increases nitric oxide levels) is an attractive therapeutic prospect. We describe a patient with limited cutaneous systemic sclerosis who presented with severe nonhealing finger ulcerations despite conventional management, who showed marked improvement with oral sildenafil.