%0 Journal Article %A Christopher Lee Colglazier %A Paul G Sutej %A Kenneth S O'Rourke %T Severe refractory fingertip ulcerations in a patient with scleroderma: successful treatment with sildenafil. %D 2005 %J The Journal of Rheumatology %P 2440-2442 %V 32 %N 12 %X Systemic sclerosis (scleroderma) is a multisystem fibrotic disease that commonly manifests with severe Raynaud's phenomenon and slow-healing cutaneous ulcerations. Reduced nitric oxide levels have been proposed to play a role in the pathogenesis of vascular disease in scleroderma, and therefore sildenafil (which increases nitric oxide levels) is an attractive therapeutic prospect. We describe a patient with limited cutaneous systemic sclerosis who presented with severe nonhealing finger ulcerations despite conventional management, who showed marked improvement with oral sildenafil. %U https://www.jrheum.org/content/jrheum/32/12/2440.full.pdf