RT Journal Article
SR Electronic
T1 Infliximab to etanercept switch in patients with spondyloarthropathies and psoriatic arthritis: preliminary data.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2183
OP 2185
VO 32
IS 11
A1 Delaunay, Caroline
A1 Farrenq, Valérie
A1 Marini-Portugal, André
A1 Cohen, Jean-David
A1 Chevalier, Xavier
A1 Claudepierre, Pascal
YR 2005
UL http://www.jrheum.org/content/32/11/2183.abstract
AB OBJECTIVE: To report early experience of switching anti-tumor necrosis factor-a (TNF-alpha) therapy from infliximab to etanercept in patients with spondyloarthropathy (SpA) and psoriatic arthritis (PsA). METHODS: Thirteen patients with various SpA (7 with ankylosing spondylitis and 6 with undifferentiated SpA) and 2 patients with PsA were receiving infliximab. Because they were experiencing inadequate response or adverse events, therapy was changed to etanercept. Patients were evaluated for response to the change in anti-TNF-alpha therapy at baseline, after 3 months, and then every 6 months. RESULTS: During the mean 10-month followup after the change in therapy, 9 of 13 patients with SpA and both patients with PsA responded to etanercept and none experienced intolerance to this agent. CONCLUSION: These data suggest that switching between anti-TNF-alpha drugs may be useful for patients with SpA who are unresponsive or intolerant to a first anti-TNF-alpha agent.