TY - JOUR T1 - Another patient with chromosome 18 deletion syndrome and juvenile rheumatoid arthritis. JF - The Journal of Rheumatology JO - J Rheumatol SP - 998 LP - 1000 VL - 31 IS - 5 AU - Paul Rosen AU - Robert J Hopkin AU - David N Glass AU - T Brent Graham Y1 - 2004/05/01 UR - http://www.jrheum.org/content/31/5/998.abstract N2 - Previously, 4 children with deletion of the long arm of chromosome 18 and chronic arthritis were reported. We present an 8-year-old girl with arthritis, atrial septal defect, external auditory canal atresia, and developmental delay. She is the fifth child reported with 18q- syndrome and juvenile rheumatoid arthritis. Evidence is mounting that genetic loci on chromosome 18 may play a role in the expression of complex autoimmune diseases. Idiopathic arthritis should be considered as a potential additional feature in 18q- syndrome. ER -