RT Journal Article
SR Electronic
T1 Granulocyte colony-stimulating factor induces disease flare in patients with antineutrophil cytoplasmic antibody-associated vasculitis.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1655
OP 1658
VO 31
IS 8
A1 Christof Iking-Konert
A1 Benedikt Ostendorf
A1 Mark Foede
A1 Rebecca Fischer-Betz
A1 Gregor Jung
A1 Maria G Haensch
A1 Matthias Schneider
YR 2004
UL http://www.jrheum.org/content/31/8/1655.abstract
AB Recombinant human granulocyte colony-stimulating factor (rhuG-CSF) is frequently given to patients with leukopenia or neutropenia caused by various underlying diseases. The treatment with rhuG-CSF is apparently safe, although cutaneous vasculitis and flares in patients with autoimmune diseases are described. We describe 2 patients with histologically proven antineutrophil cytoplasmic antibody-associated systemic vasculitis with disease flares after administration of rhuG-CSF, given to improve collection of stem cells prior to autologous stem cell transplantation.