PT  - JOURNAL ARTICLE
AU  - Sally Aspegren Kendall
AU  - Malika Lone Chenoufi Schaadt
AU  - Lykke Bjerglund Graff
AU  - Irene Wittrup
AU  - Hanne Malmskov
AU  - Kim Krogsgaard
AU  - Else-Marie Bartels
AU  - Henning Bliddal
AU  - Bente Danneskiold-Samsøe
TI  - No effect of antiviral (valacyclovir) treatment in fibromyalgia: a double blind, randomized study.
DP  - 2004 Apr 01
TA  - The Journal of Rheumatology
PG  - 783--784
VI  - 31
IP  - 4
4099  - http://www.jrheum.org/content/31/4/783.short
4100  - http://www.jrheum.org/content/31/4/783.full
SO  - J Rheumatol2004 Apr 01; 31
AB  - OBJECTIVE: To investigate the effect of an antiviral compound, valacyclovir, on pain and tenderness in patients with the fibromyalgia (FM) syndrome. METHODS: Sixty patients were randomized into a double blind, placebo controlled 6 week trial. Primary outcome was pain intensity change (on visual analog scale). Secondary outcome measures were tender points (myalgic score) and Fibromyalgia Impact Questionnaire (FIQ). RESULTS: Fifty-two patients completed the study. The numbers of dropouts due to adverse events were equal in valacyclovir (2) and placebo (2) groups. The effect of valacyclovir on pain and tenderness and FIQ did not differ from placebo. CONCLUSION: Valacyclovir cannot be recommended as a therapy for FM at this point.