PT - JOURNAL ARTICLE AU - Kendall, Sally Aspegren AU - Schaadt, Malika Lone Chenoufi AU - Graff, Lykke Bjerglund AU - Wittrup, Irene AU - Malmskov, Hanne AU - Krogsgaard, Kim AU - Bartels, Else-Marie AU - Bliddal, Henning AU - Danneskiold-Samsøe, Bente TI - No effect of antiviral (valacyclovir) treatment in fibromyalgia: a double blind, randomized study. DP - 2004 Apr 01 TA - The Journal of Rheumatology PG - 783--784 VI - 31 IP - 4 4099 - http://www.jrheum.org/content/31/4/783.short 4100 - http://www.jrheum.org/content/31/4/783.full SO - J Rheumatol2004 Apr 01; 31 AB - OBJECTIVE: To investigate the effect of an antiviral compound, valacyclovir, on pain and tenderness in patients with the fibromyalgia (FM) syndrome. METHODS: Sixty patients were randomized into a double blind, placebo controlled 6 week trial. Primary outcome was pain intensity change (on visual analog scale). Secondary outcome measures were tender points (myalgic score) and Fibromyalgia Impact Questionnaire (FIQ). RESULTS: Fifty-two patients completed the study. The numbers of dropouts due to adverse events were equal in valacyclovir (2) and placebo (2) groups. The effect of valacyclovir on pain and tenderness and FIQ did not differ from placebo. CONCLUSION: Valacyclovir cannot be recommended as a therapy for FM at this point.