RT Journal Article
SR Electronic
T1 Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 614
OP 616
VO 31
IS 3
A1 Francisco Olán
A1 Margarita Portela
A1 Carmen Navarro
A1 Miguel Gaxiola
A1 Luis H Silveira
A1 Victor Ruiz
A1 Manuel Martínez-Lavín
YR 2004
UL http://www.jrheum.org/content/31/3/614.abstract
AB Vascular endothelial growth factor (VEGF) is a cytokine overexpressed in hypoxic and malignant pathologies. VEGF induces vascular hyperplasia, new bone formation, and edema. These histological abnormalities characterize hypertrophic osteoarthropathy. We describe a case of pulmonary hypertrophic osteoarthropathy with high circulating VEGF levels. Removal of the lung tumor led to a dramatic disappearance of the skeletal abnormalities and to reduction of circulating VEGF levels. Histochemical studies of the excised tumor confirmed abnormal VEGF production.