RT Journal Article
SR Electronic
T1 Common aspects of human and primate seronegative arthritis.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2300
OP 2304
VO 31
IS 11
A1 Kimme L Hyrich
A1 Tae-Hwan Kim
A1 Ursula Payne
A1 Xiang Zhang
A1 Basil Chiu
A1 Kay Mehren
A1 Robert D Inman
YR 2004
UL http://www.jrheum.org/content/31/11/2300.abstract
AB A 27-year-old female lowland gorilla developed an asymmetric oligoarthritis 3 months post-partum.There was no evidence of an antecedent gastrointestinal or genitourinary infection. Serum was negative for rheumatoid factor and antinuclear antibody. Synovial fluid revealed 2000 white blood cells with negative cultures and polarized microscopy. Studies on synoviocytes were the following: (1) FACS analysis revealed surface expression of a B27-like epitope of the cells. (2) Analysis of intracellular clearance kinetics of arthritogenic organisms showed peak intracellular colony-forming units at 48 hours after bacterial invasion, and clearance by 13 days post-invasion. (3) Interferon-y (0.1-10.0 ng/ml)accelerated intracellular microbicidal pathways in a dose-dependent fashion. These findings closely parallel those seen in human synoviocytes of patients with spondyloarthropathy. Primate and human seronegative arthritis share clinical and immunologic features, as well as aspects of host:pathogen defense mechanisms. The interplay of genetic and microbial factors underlying this arthritis appears to be conserved across these species boundaries.