@article {Alenius2230, author = {Gerd-Marie Alenius and Camilla Friberg and Staffan Nilsson and Jan Wahlstr{\"o}m and Solbritt Rantap{\"a}{\"a} Dahlqvist and Lena Samuelsson}, title = {Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis.}, volume = {31}, number = {11}, pages = {2230--2235}, year = {2004}, publisher = {The Journal of Rheumatology}, abstract = {OBJECTIVE: To analyze the association of several autoimmune disease susceptibility loci in a population of patients with psoriasis and defined joint disease from northern Sweden. METHOD: One hundred twenty patients with psoriasis and defined joint disease were examined clinically, radiologically, and with laboratory-based analyses. Disease classification was based on peripheral and/or axial engagement. The tumor necrosis factor (TNF) locus, 1q21 (PSORS4), 3q21 (PSORS5), 8q24, 16q21, and the CTLA4 gene were analyzed using a total of 38 microsatellite markers and 2 single nucleotide polymorphisms (SNP). Ninety-four controls with the same ethnic background as the patients were randomly selected from the same region of Sweden. RESULTS: An association was found with one of the markers in the TNFB locus within the HLA region (p = 0.012, pc = 0.024). Three markers at the PSORS4 locus on chromosome 1q21 and 2 markers at the 8q24 locus showed nominal p values of \< 0.05. After applying the Bonferroni correction for multiple analyses these markers did not reach significance. No other marker showed significant association. In a subgroup of the patients, possible linkage disequilibrium between the TNFB123 and HLA-B antigens, B17, B27, B37, B44, and B62 was analyzed. A significant linkage (p = 0.0001) was found. CONCLUSION: We identified an association between psoriatic arthritis and one of the microsatellite markers within the TNFB locus at the HLA region on chromosome 6. Linkage disequilibrium between TNFB123 and certain HLA-B antigens was found.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/31/11/2230}, eprint = {https://www.jrheum.org/content/31/11/2230.full.pdf}, journal = {The Journal of Rheumatology} }