TY - JOUR T1 - Alpha1-antitrypsin replacement therapy controls fibromyalgia symptoms in 2 patients with PI ZZ alpha1-antitrypsin deficiency. JF - The Journal of Rheumatology JO - J Rheumatol SP - 2082 LP - 2085 VL - 31 IS - 10 AU - Ignacio Blanco AU - Hortensia Canto AU - Frederick Joseph de Serres AU - Enrique Fernandez-Bustillo AU - Maria Carmen Rodríguez Y1 - 2004/10/01 UR - http://www.jrheum.org/content/31/10/2082.abstract N2 - Two Spanish sisters with alpha1-antitrypsin (AAT) deficiency and fibromyalgia (FM) started AAT replacement therapy with commercial alpha1-antitrypsin infusions in 1992. They both experienced a rapid, progressive, and constant control of their FM symptoms during the next 6 years (1992-98). However, in 1998, treatment of both patients was affected by the worldwide commercial shortage of AAT replacement therapy; replacement therapy infusions were halted for about 4-6 consecutive months every year for 5 years. As a result, we observed a striking recurrence of FM symptoms. Equally striking was the total disappearance of these symptoms when AAT replacement therapy infusions were resumed. ER -