RT Journal Article SR Electronic T1 Etanercept ameliorates sarcoidosis arthritis and skin disease. JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1864 OP 1867 VO 30 IS 8 A1 Dinesh Khanna A1 Michael R Liebling A1 James S Louie YR 2003 UL http://www.jrheum.org/content/30/8/1864.abstract AB Sarcoidosis is a systemic disorder of unknown etiology characterized by its pathological hallmark, the noncaseating granuloma. In granulomatous diseases, the proinflammatory peptide mediators, including tumor necrosis factor-alpha (TNF-alpha), are increased in the blood and fluids surrounding the activated macrophages. We describe a patient with chronic sarcoidosis arthropathy and lupus pernio resistant to corticosteroids and disease modifying antirheumatic agents, who responded to the addition of etanercept. We discuss the possible mechanisms of action of anti-TNF agents in granulomatous diseases and suggest that chronic, resistant sarcoidosis requires combination immunosuppressive therapy.