RT Journal Article SR Electronic T1 Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction. JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 2503 OP 2505 VO 30 IS 11 A1 Johnson, Sindhu A1 Iazzetta, John A1 Dewar, Catharine YR 2003 UL http://www.jrheum.org/content/30/11/2503.abstract AB Yohimbine is a selective alpha-2 adrenergic antagonist that has been used in the pharmacologic management of erectile dysfunction (ED). We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.