RT Journal Article
SR Electronic
T1 Suppressive effect of hochu-ekki-to on collagen induced arthritis in DBA1J mice.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1601
OP 1608
VO 29
IS 8
A1 Le Xuan Hai
A1 Toshiaki Kogure
A1 Atsushi Niizawa
A1 Hiroshi Fujinaga
A1 Iwao Sakakibara
A1 Yutaka Shimada
A1 Hiroshi Watanabe
A1 Katsutoshi Terasawa
YR 2002
UL http://www.jrheum.org/content/29/8/1601.abstract
AB OBJECTIVE: To investigate the effect of hochu-ekki-to (HET) decoction on the development of collagen-induced arthritis (CIA) in mice. METHODS: CIA was induced in male DBA/IJ mice by immunization with 2 injections of bovine type II collagen (CII). HET was orally administered at different doses and with different schedules. The incidence of arthritis, arthritis index, levels of anti-CII antibody, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) and lymphocyte subsets were examined. RESULTS: HET caused suppression of CIA development in a dose dependent fashion and exerted a suppressive effect on CIA when administered from the first CII immunization or from the onset of CIA, but not when administered for 2 weeks before CII immunization. HET inhibited the production of specific anti-CII antibody, IL-6, and TNF-alpha, and tended to normalize the proportions of cells in lymphocyte subsets. CONCLUSION: HET suppresses the development of CIA, and HET redistributes the population of lymphocytes in lymph node and blood and inhibits IL-6 and TNF-alpha secretion in CIA mice.