@article {Hai1601, author = {Le Xuan Hai and Toshiaki Kogure and Atsushi Niizawa and Hiroshi Fujinaga and Iwao Sakakibara and Yutaka Shimada and Hiroshi Watanabe and Katsutoshi Terasawa}, title = {Suppressive effect of hochu-ekki-to on collagen induced arthritis in DBA1J mice.}, volume = {29}, number = {8}, pages = {1601--1608}, year = {2002}, publisher = {The Journal of Rheumatology}, abstract = {OBJECTIVE: To investigate the effect of hochu-ekki-to (HET) decoction on the development of collagen-induced arthritis (CIA) in mice. METHODS: CIA was induced in male DBA/IJ mice by immunization with 2 injections of bovine type II collagen (CII). HET was orally administered at different doses and with different schedules. The incidence of arthritis, arthritis index, levels of anti-CII antibody, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) and lymphocyte subsets were examined. RESULTS: HET caused suppression of CIA development in a dose dependent fashion and exerted a suppressive effect on CIA when administered from the first CII immunization or from the onset of CIA, but not when administered for 2 weeks before CII immunization. HET inhibited the production of specific anti-CII antibody, IL-6, and TNF-alpha, and tended to normalize the proportions of cells in lymphocyte subsets. CONCLUSION: HET suppresses the development of CIA, and HET redistributes the population of lymphocytes in lymph node and blood and inhibits IL-6 and TNF-alpha secretion in CIA mice.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/29/8/1601}, eprint = {https://www.jrheum.org/content/29/8/1601.full.pdf}, journal = {The Journal of Rheumatology} }