TY - JOUR T1 - No association of vitamin D receptor gene start codon fok 1 polymorphisms in Chinese patients with systemic lupus erythematosus. JF - The Journal of Rheumatology JO - J Rheumatol SP - 1211 LP - 1213 VL - 29 IS - 6 AU - Chung-Ming Huang AU - Mei-Chen Wu AU - Jer-Yuarn Wu AU - Fuu-Jen Tsai Y1 - 2002/06/01 UR - http://www.jrheum.org/content/29/6/1211.abstract N2 - OBJECTIVE: To examine whether the start codon Fok I of the vitamin D receptor (VDR) gene polymorphism is a marker of susceptibility to or severity of systemic lupus erythematosus (SLE) in Chinese patients in Taiwan. METHODS: A control group of 90 healthy people and 52 patients with SLE were examined. Using polymerase chain reaction (PCR) based restriction analysis, we evaluated the relationship between Fok I polymorphisms and SLE, where an unexcisable length was determined to be 265 bp (FF), and the 2 fragments measuring 169 bp and 96 bp were determined to be excisable lengths (ff). RESULTS: For the genotype of VDR Fok I start codon polymorphism, there were no statistically significant differences between the 2 groups (chi-squared test, p = 0.07). Additionally, we did not detect any association of VDR genotype with the clinical and laboratory profiles in SLE patients. CONCLUSION: Our results suggest that the vitamin D receptor Fok I start codon polymorphism is not related to patients with SLE in Taiwan. ER -