TY - JOUR T1 - Treatment of calcinosis in juvenile dermatomyositis with probenecid: the role of phosphorus metabolism in the development of calcifications. JF - The Journal of Rheumatology JO - J Rheumatol SP - 1129 LP - 1132 VL - 28 IS - 5 AU - L Harel AU - G Harel AU - L Korenreich AU - R Straussberg AU - J Amir Y1 - 2001/05/01 UR - http://www.jrheum.org/content/28/5/1129.abstract N2 - OBJECTIVE: To report the efficacy of probenecid for calcinosis of juvenile dermatomyositis (JDM) and assess the changes in phosphorus metabolism during treatment. METHODS: Biochemical studies of calcium and phosphorus metabolism were performed in a 9-year-old girl with JDM and extensive calcifications before and during probenecid treatment. RESULTS: The calcifications resolved over 18 months of treatment. Probenecid was found to be effective in reducing calcifications by increasing renal phosphate clearance. CONCLUSIONS: The tendency for calcifications in some patients with JDM might be related to an increase in renal phosphate reclamation, and therefore, probenecid treatment may be effective in these patients. ER -