PT  - JOURNAL ARTICLE
AU  - L Harel
AU  - G Harel
AU  - L Korenreich
AU  - R Straussberg
AU  - J Amir
TI  - Treatment of calcinosis in juvenile dermatomyositis with probenecid: the role of phosphorus metabolism in the development of calcifications.
DP  - 2001 May 01
TA  - The Journal of Rheumatology
PG  - 1129--1132
VI  - 28
IP  - 5
4099  - http://www.jrheum.org/content/28/5/1129.short
4100  - http://www.jrheum.org/content/28/5/1129.full
SO  - J Rheumatol2001 May 01; 28
AB  - OBJECTIVE: To report the efficacy of probenecid for calcinosis of juvenile dermatomyositis (JDM) and assess the changes in phosphorus metabolism during treatment. METHODS: Biochemical studies of calcium and phosphorus metabolism were performed in a 9-year-old girl with JDM and extensive calcifications before and during probenecid treatment. RESULTS: The calcifications resolved over 18 months of treatment. Probenecid was found to be effective in reducing calcifications by increasing renal phosphate clearance. CONCLUSIONS: The tendency for calcifications in some patients with JDM might be related to an increase in renal phosphate reclamation, and therefore, probenecid treatment may be effective in these patients.