RT Journal Article SR Electronic T1 Effectiveness and Safety of Etanercept in Patients with Psoriatic Arthritis in a Canadian Clinical Practice Setting: The REPArE Trial JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1355 OP 1362 DO 10.3899/jrheum.100698 VO 38 IS 7 A1 DAFNA D. GLADMAN A1 CLAIRE BOMBARDIER A1 CARTER THORNE A1 BOULOS HARAOUI A1 MAJED KHRAISHI A1 PROTON RAHMAN A1 WILLIAM BENSEN A1 JERRY SYROTUIK A1 MELANIE POULIN-COSTELLO YR 2011 UL http://www.jrheum.org/content/38/7/1355.abstract AB Objective. To describe the longterm effectiveness and safety of etanercept in Canadian patients with psoriatic arthritis (PsA), treated over 24 months in clinical practice. Methods. Patients with active PsA (≥ 3 tender and ≥ 3 swollen joints) were recruited from 22 centers. Etanercept was administered at 50 mg/week subcutaneously. In addition to clinical assessment of skin and joint disease, conducted at baseline and at Months 6, 12, 18, and 24, regular patient interviews were conducted by telephone. Patient responses related to health status, disability, and work productivity were scored using the patient global assessment tool, the Health Assessment Questionnaire (HAQ), the Health and Labour Questionnaire (HLQ), and the Fatigue Severity Scale. Results. Out of 110 patients, 71 (65%) maintained etanercept treatment through the end of our study. All clinical measures of disease severity, including joint tenderness/pain, joint swelling, and Psoriasis Area and Severity Index score, improved significantly between baseline and Month 6 of etanercept treatment and remained constant thereafter. By the end of our study, 79% of patients achieved a Psoriatic Arthritis Response Criteria response, and 56% of patients achieved a 0.5-point improvement on HAQ, indicating clinically significant improvement in disability; 14% of patients finished our study free of disability (HAQ = 0). Patients’ work productivity and fatigue improved significantly in parallel with these clinical and functional improvements. Conclusion. Continuous treatment with etanercept over 2 years in a clinical setting improved clinical symptoms of PsA while reducing fatigue, improving work productivity, and ameliorating or eliminating disability.