RT Journal Article
SR Electronic
T1 Hepatic Involvement in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Clinical and Therapeutic Insights From 2 Cases
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.2026-0131
DO 10.3899/jrheum.2026-0131
A1 Romano, Stefano
A1 Mastrolia, Maria Vincenza
A1 Bracaglia, Claudia
A1 Minoia, Francesca
A1 Giani, Teresa
A1 Caiello, Ivan
A1 Maccora, Ilaria
A1 Rossano, Martina
A1 Maniscalco, Valerio
A1 Marrani, Edoardo
A1 Pagnini, Ilaria
A1 Simonini, Gabriele
YR 2026
UL http://www.jrheum.org/content/early/2026/07/09/jrheum.2026-0131.abstract
AB We read with interest the manuscript entitled "Hepatic Manifestations in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome" by Eloseily et al,1 describing 4 patients with systemic juvenile idiopathic arthritis (sJIA) complicated by macrophage activation syndrome (MAS) and hepatic involvement and treated with emapalumab. We report our experience with this subgroup of patients, describing 2 cases treated at Meyer Children's Hospital in which patients experienced multiple hepatic relapses requiring a combined treatment approach.