PT  - JOURNAL ARTICLE
AU  - Romano, Stefano
AU  - Mastrolia, Maria Vincenza
AU  - Bracaglia, Claudia
AU  - Minoia, Francesca
AU  - Giani, Teresa
AU  - Caiello, Ivan
AU  - Maccora, Ilaria
AU  - Rossano, Martina
AU  - Maniscalco, Valerio
AU  - Marrani, Edoardo
AU  - Pagnini, Ilaria
AU  - Simonini, Gabriele
TI  - Hepatic Involvement in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Clinical and Therapeutic Insights From 2 Cases
AID  - 10.3899/jrheum.2026-0131
DP  - 2026 Jul 15
TA  - The Journal of Rheumatology
PG  - jrheum.2026-0131
4099  - http://www.jrheum.org/content/early/2026/07/09/jrheum.2026-0131.short
4100  - http://www.jrheum.org/content/early/2026/07/09/jrheum.2026-0131.full
AB  - We read with interest the manuscript entitled "Hepatic Manifestations in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome" by Eloseily et al,1 describing 4 patients with systemic juvenile idiopathic arthritis (sJIA) complicated by macrophage activation syndrome (MAS) and hepatic involvement and treated with emapalumab. We report our experience with this subgroup of patients, describing 2 cases treated at Meyer Children's Hospital in which patients experienced multiple hepatic relapses requiring a combined treatment approach.